Human Glutaminase (GLS) activation kit by CRISPRa

CAT#: GA101831

GLS CRISPRa kit - CRISPR gene activation of human glutaminase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLS
• Locus ID: 2744
• Kit Components:

  GA101831G1, Glutaminase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101831G2, Glutaminase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101831G3, Glutaminase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256310, NM_014905
• Synonyms: AAD20; GAC; GAM; GLS1; KGA
• Summary: 'This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]'