Human Glutamine Synthetase (GLUL) activation kit by CRISPRa

CAT#: GA101835

GLUL CRISPRa kit - CRISPR gene activation of human glutamate-ammonia ligase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLUL
• Locus ID: 2752
• Kit Components:

  GA101835G1, Glutamine Synthetase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101835G2, Glutamine Synthetase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101835G3, Glutamine Synthetase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033044, NM_001033056, NM_002065
• Synonyms: GLNS; GS; PIG43; PIG59
• Summary: 'The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]'