Human GM2A activation kit by CRISPRa

CAT#: GA101836

GM2A CRISPRa kit - CRISPR gene activation of human GM2 ganglioside activator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GM2A
• Locus ID: 2760
• Kit Components:

  GA101836G1, GM2A gRNA vector 1 in pCas-Guide-CRISPRa

  GA101836G2, GM2A gRNA vector 2 in pCas-Guide-CRISPRa

  GA101836G3, GM2A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000405, NM_001167607
• Synonyms: GM2-AP; SAP-3
• Summary: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]