Human GMDS activation kit by CRISPRa

CAT#: GA101837

GMDS CRISPRa kit - CRISPR gene activation of human GDP-mannose 4,6-dehydratase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GMDS
• Locus ID: 2762
• Kit Components:

  GA101837G1, GMDS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101837G2, GMDS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101837G3, GMDS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001253846, NM_001500
• Synonyms: GMD; SDR3E1
• Summary: 'GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]'