Human GnRH (GNRH1) activation kit by CRISPRa

CAT#: GA101866

GNRH1 CRISPRa kit - CRISPR gene activation of human gonadotropin releasing hormone 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GNRH1
• Locus ID: 2796
• Kit Components:

  GA101866G1, GNRH1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA101866G2, GNRH1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA101866G3, GNRH1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000825, NM_001083111
• Synonyms: GNRH; GRH; HH12; LHRH; LNRH
• Summary: This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]