Human GRIA4 activation kit by CRISPRa

CAT#: GA101949

GRIA4 CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor AMPA type subunit 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRIA4
• Locus ID: 2893
• Kit Components:

  GA101949G1, GRIA4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101949G2, GRIA4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101949G3, GRIA4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000829, NM_001077243, NM_001077244, NM_001112812, NR_046356
• Synonyms: GluA4; GLUR4; GLUR4C; GLURD
• Summary: 'Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]'