Human NMDAR2A (GRIN2A) activation kit by CRISPRa

CAT#: GA101959

GRIN2A CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor NMDA type subunit 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRIN2A
• Locus ID: 2903
• Kit Components:

  GA101959G1, NMDAR2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101959G2, NMDAR2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101959G3, NMDAR2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000833, NM_001134407, NM_001134408
• Synonyms: EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A
• Summary: 'This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]'