Human NMDAR2B (GRIN2B) activation kit by CRISPRa

CAT#: GA101960

GRIN2B CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor NMDA type subunit 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRIN2B
• Locus ID: 2904
• Kit Components:

  GA101960G1, NMDAR2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101960G2, NMDAR2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101960G3, NMDAR2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000834
• Synonyms: EIEE27; GluN2B; hNR3; MRD6; NMDAR2B; NR2B
• Summary: 'This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017]'