Human NMDAR2C (GRIN2C) activation kit by CRISPRa

CAT#: GA101961

GRIN2C CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor NMDA type subunit 2C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRIN2C
• Locus ID: 2905
• Kit Components:

  GA101961G1, NMDAR2C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101961G2, NMDAR2C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101961G3, NMDAR2C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000835, NM_001278553, NR_103735
• Synonyms: GluN2C; NMDAR2C; NR2C
• Summary: 'This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]'