Human Gastrin Releasing Peptide (GRP) activation kit by CRISPRa

CAT#: GA101977

GRP CRISPRa kit - CRISPR gene activation of human gastrin releasing peptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRP
• Locus ID: 2922
• Kit Components:

  GA101977G1, Gastrin Releasing Peptide gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101977G2, Gastrin Releasing Peptide gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101977G3, Gastrin Releasing Peptide gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001012512, NM_001012513, NM_002091
• Synonyms: BN; GRP-10; preproGRP; proGRP
• Summary: 'This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]'