Human Glutathione Synthetase (GSS) activation kit by CRISPRa

CAT#: GA101987

GSS CRISPRa kit - CRISPR gene activation of human glutathione synthetase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GSS
• Locus ID: 2937
• Kit Components:

  GA101987G1, Glutathione Synthetase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101987G2, Glutathione Synthetase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101987G3, Glutathione Synthetase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000178, NM_001322494, NM_001322495
• Synonyms: GSHS; HEL-S-64p; HEL-S-88n
• Summary: 'Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]'