Human MSH6 activation kit by CRISPRa

CAT#: GA102001

MSH6 CRISPRa kit - CRISPR gene activation of human mutS homolog 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MSH6
• Locus ID: 2956
• Kit Components:

  GA102001G1, MSH6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA102001G2, MSH6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA102001G3, MSH6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000179, NM_001281492, NM_001281493, NM_001281494
• Synonyms: GTBP; GTMBP; HNPCC5; HSAP; p160
• Summary: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]