Human Histone H1.5 (HIST1H1B) activation kit by CRISPRa

CAT#: GA102047

HIST1H1B CRISPRa kit - CRISPR gene activation of human histone cluster 1 H1 family member b

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: H1-5
• Locus ID: 3009
• Kit Components:

  GA102047G1, Histone H1.5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102047G2, Histone H1.5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102047G3, Histone H1.5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005322
• Synonyms: H1; H1.5; H1B; H1F5; H1s-3
• Summary: 'Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]'