Human HADHB activation kit by CRISPRa

CAT#: GA102062

HADHB CRISPRa kit - CRISPR gene activation of human hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HADHB
• Locus ID: 3032
• Kit Components:

  GA102062G1, HADHB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102062G2, HADHB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102062G3, HADHB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000183, NM_001281512, NM_001281513
• Synonyms: ECHB; MSTP029; MTPB; TP-BETA
• Summary: 'This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]'