Human HBA-T2 (HBB) activation kit by CRISPRa

CAT#: GA102072

HBB CRISPRa kit - CRISPR gene activation of human hemoglobin subunit beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HBB
• Locus ID: 3043
• Kit Components:

  GA102072G1, HBA-T2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102072G2, HBA-T2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102072G3, HBA-T2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000518
• Synonyms: beta-globin; CD113t-C
• Summary: 'The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]'