Human HCFC1 activation kit by CRISPRa

CAT#: GA102081

HCFC1 CRISPRa kit - CRISPR gene activation of human host cell factor C1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HCFC1
• Locus ID: 3054
• Kit Components:

  GA102081G1, HCFC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102081G2, HCFC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102081G3, HCFC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005334
• Synonyms: CFF; HCF; HCF-1; HCF1; HFC1; MRX3; PPP1R89; VCAF
• Summary: 'This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]'