Human HDAC1 activation kit by CRISPRa

CAT#: GA102088

HDAC1 CRISPRa kit - CRISPR gene activation of human histone deacetylase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HDAC1
• Locus ID: 3065
• Kit Components:

  GA102088G1, HDAC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102088G2, HDAC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102088G3, HDAC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004964
• Synonyms: GON-10; HD1; RPD3; RPD3L1
• Summary: 'Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]'