Human CFHL1 (CFHR1) activation kit by CRISPRa

CAT#: GA102099

CFHR1 CRISPRa kit - CRISPR gene activation of human complement factor H related 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CFHR1
• Locus ID: 3078
• Kit Components:

  GA102099G1, CFHL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102099G2, CFHL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102099G3, CFHL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002113
• Synonyms: CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2
• Summary: 'This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]'