Human HGF activation kit by CRISPRa

CAT#: GA102102

HGF CRISPRa kit - CRISPR gene activation of human hepatocyte growth factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HGF
• Locus ID: 3082
• Kit Components:

  GA102102G1, HGF gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102102G2, HGF gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102102G3, HGF gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000601, NM_001010931, NM_001010932, NM_001010933, NM_001010934
• Synonyms: DFNB39; F-TCF; HGFB; HPTA; SF
• Summary: 'This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]'