Human Hexokinase 1 (HK1) activation kit by CRISPRa

CAT#: GA102113

HK1 CRISPRa kit - CRISPR gene activation of human hexokinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HK1
• Locus ID: 3098
• Kit Components:

  GA102113G1, Hexokinase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102113G2, Hexokinase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102113G3, Hexokinase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000188, NM_001322364, NM_001322365, NM_001322366, NM_001322367, NM_033496, NM_033497, NM_033498, NM_033500, NM_001358263
• Synonyms: hexokinase; HK; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1
• Summary: 'Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]'