Human HMBS activation kit by CRISPRa

CAT#: GA102144

HMBS CRISPRa kit - CRISPR gene activation of human hydroxymethylbilane synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMBS
• Locus ID: 3145
• Kit Components:

  GA102144G1, HMBS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102144G2, HMBS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102144G3, HMBS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000190, NM_001024382, NM_001258208, NM_001258209
• Synonyms: PBG-D; PBGD; PORC; UPS
• Summary: 'This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]'