Human HMG1 (HMGB1) activation kit by CRISPRa

CAT#: GA102145

HMGB1 CRISPRa kit - CRISPR gene activation of human high mobility group box 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMGB1
• Locus ID: 3146
• Kit Components:

  GA102145G1, HMG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102145G2, HMG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102145G3, HMG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313892, NM_001313893, NM_002128, NM_001363661, NM_001370339, NM_001370340, NM_001370341
• Synonyms: HMG1; HMG3; SBP-1
• Summary: 'This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]'