Human HMGCL activation kit by CRISPRa

CAT#: GA102150

HMGCL CRISPRa kit - CRISPR gene activation of human 3-hydroxy-3-methylglutaryl-CoA lyase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMGCL
• Locus ID: 3155
• Kit Components:

  GA102150G1, HMGCL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102150G2, HMGCL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102150G3, HMGCL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000191, NM_001166059
• Synonyms: HL
• Summary: 'The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]'