Human HMGCS2 activation kit by CRISPRa

CAT#: GA102153

HMGCS2 CRISPRa kit - CRISPR gene activation of human 3-hydroxy-3-methylglutaryl-CoA synthase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMGCS2
• Locus ID: 3158
• Kit Components:

  GA102153G1, HMGCS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102153G2, HMGCS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102153G3, HMGCS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166107, NM_005518
• Synonyms: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); hydroxymethylglutaryl-CoA synthase 2; OTTHUMP00000013928
• Summary: 'The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]'