Human NUR77 (NR4A1) activation kit by CRISPRa

CAT#: GA102158

NR4A1 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 4 group A member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR4A1
• Locus ID: 3164
• Kit Components:

  GA102158G1, NUR77 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102158G2, NUR77 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102158G3, NUR77 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001202233, NM_001202234, NM_002135, NM_173157, NM_173158
• Synonyms: GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3
• Summary: 'This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]'