Human HNF 4 alpha (HNF4A) activation kit by CRISPRa

CAT#: GA102164

HNF4A CRISPRa kit - CRISPR gene activation of human hepatocyte nuclear factor 4 alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HNF4A
• Locus ID: 3172
• Kit Components:

  GA102164G1, HNF 4 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102164G2, HNF 4 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102164G3, HNF 4 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000457, NM_001030003, NM_001030004, NM_001258355, NM_001287182, NM_001287183, NM_001287184, NM_175914, NM_178849, NM_178850
• Synonyms: FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
• Summary: 'The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]'