Human hnRNP F (HNRNPF) activation kit by CRISPRa

CAT#: GA102174

HNRNPF CRISPRa kit - CRISPR gene activation of human heterogeneous nuclear ribonucleoprotein F

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HNRNPF
• Locus ID: 3185
• Kit Components:

  GA102174G1, hnRNP F gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102174G2, hnRNP F gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102174G3, hnRNP F gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098204, NM_001098205, NM_001098206, NM_001098207, NM_001098208, NM_004966
• Synonyms: HNRPF; mcs94-1; OK/SW-cl.23
• Summary: 'This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]'