Human hnRNP K (HNRNPK) activation kit by CRISPRa

CAT#: GA102178

HNRNPK CRISPRa kit - CRISPR gene activation of human heterogeneous nuclear ribonucleoprotein K

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HNRNPK
• Locus ID: 3190
• Kit Components:

  GA102178G1, hnRNP K gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102178G2, hnRNP K gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102178G3, hnRNP K gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318186, NM_001318187, NM_001318188, NM_002140, NM_031262, NM_031263
• Synonyms: CSBP; HNRPK; TUNP
• Summary: 'This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]'