Human HOXD8 activation kit by CRISPRa

CAT#: GA102216

HOXD8 CRISPRa kit - CRISPR gene activation of human homeobox D8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HOXD8
• Locus ID: 3234
• Kit Components:

  GA102216G1, HOXD8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102216G2, HOXD8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102216G3, HOXD8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199746, NM_001199747, NM_019558
• Synonyms: HOX4; HOX4E; HOX5.4
• Summary: 'This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]'