Human Hydroxysteroid (17 beta) Dehydrogenase 4 (HSD17B4) activation kit by CRISPRa

CAT#: GA102250

HSD17B4 CRISPRa kit - CRISPR gene activation of human hydroxysteroid 17-beta dehydrogenase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HSD17B4
• Locus ID: 3295
• Kit Components:

  GA102250G1, Hydroxysteroid (17 beta) Dehydrogenase 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102250G2, Hydroxysteroid (17 beta) Dehydrogenase 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102250G3, Hydroxysteroid (17 beta) Dehydrogenase 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000414, NM_001199291, NM_001199292, NM_001292027, NM_001292028
• Synonyms: DBP; MFE-2; MPF-2; PRLTS1; SDR8C1
• Summary: 'The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]'