Human Hsp40 (DNAJB1) activation kit by CRISPRa

CAT#: GA102272

DNAJB1 CRISPRa kit - CRISPR gene activation of human DnaJ heat shock protein family (Hsp40) member B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNAJB1
• Locus ID: 3337
• Kit Components:

  GA102272G1, Hsp40 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102272G2, Hsp40 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102272G3, Hsp40 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001300914, NM_001313964, NM_006145
• Synonyms: Hdj1; Hsp40; HSPF1; RSPH16B; Sis1
• Summary: 'This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]'