Human 5 HT 2A (HTR2A) activation kit by CRISPRa

CAT#: GA102284

HTR2A CRISPRa kit - CRISPR gene activation of human 5-hydroxytryptamine receptor 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HTR2A
• Locus ID: 3356
• Kit Components:

  GA102284G1, 5 HT 2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102284G2, 5 HT 2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102284G3, 5 HT 2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000621, NM_001165947
• Synonyms: 5-HT2A; HTR2
• Summary: 'This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]'