Human Isoleucyl tRNA synthetase (IARS) activation kit by CRISPRa

CAT#: GA102296

IARS CRISPRa kit - CRISPR gene activation of human isoleucyl-tRNA synthetase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IARS1
• Locus ID: 3376
• Kit Components:

  GA102296G1, Isoleucyl tRNA synthetase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102296G2, Isoleucyl tRNA synthetase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102296G3, Isoleucyl tRNA synthetase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002161, NM_013417, NR_073446
• Synonyms: GRIDHH; IARS1; ILERS; ILRS; IRS; PRO0785
• Summary: 'Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]'