Human Bone Sialoprotein (IBSP) activation kit by CRISPRa

CAT#: GA102297

IBSP CRISPRa kit - CRISPR gene activation of human integrin binding sialoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IBSP
• Locus ID: 3381
• Kit Components:

  GA102297G1, IBSP gRNA vector 1 in pCas-Guide-CRISPRa

  GA102297G2, IBSP gRNA vector 2 in pCas-Guide-CRISPRa

  GA102297G3, IBSP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004967
• Synonyms: BNSP; BSP; BSP-II; SP-II
• Summary: The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]