Human ICAM3 activation kit by CRISPRa

CAT#: GA102301

ICAM3 CRISPRa kit - CRISPR gene activation of human intercellular adhesion molecule 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ICAM3
• Locus ID: 3385
• Kit Components:

  GA102301G1, ICAM3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102301G2, ICAM3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102301G3, ICAM3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320605, NM_001320606, NM_001320608, NM_002162
• Synonyms: CD50; CDW50; ICAM-R
• Summary: 'The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]'