Human IDUA activation kit by CRISPRa

CAT#: GA102317

IDUA CRISPRa kit - CRISPR gene activation of human iduronidase alpha-L-

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IDUA
• Locus ID: 3425
• Kit Components:

  GA102317G1, IDUA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102317G2, IDUA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102317G3, IDUA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000203, NR_110313, NM_001363576
• Synonyms: IDA; MPS1
• Summary: 'This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]'