Human IFI16 activation kit by CRISPRa

CAT#: GA102319

IFI16 CRISPRa kit - CRISPR gene activation of human interferon gamma inducible protein 16

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IFI16
• Locus ID: 3428
• Kit Components:

  GA102319G1, IFI16 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102319G2, IFI16 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102319G3, IFI16 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206567, NM_005531, NM_001364867
• Synonyms: IFNGIP1; PYHIN2
• Summary: 'This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]'