Human SP110 activation kit by CRISPRa

CAT#: GA102322

SP110 CRISPRa kit - CRISPR gene activation of human SP110 nuclear body protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SP110
• Locus ID: 3431
• Kit Components:

  GA102322G1, SP110 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102322G2, SP110 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102322G3, SP110 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185015, NM_004509, NM_004510, NM_080424
• Synonyms: IFI41; IFI75; IPR1; VODI
• Summary: 'The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]'