Human Interferon alpha 2 (IFNA2) activation kit by CRISPRa

CAT#: GA102327

IFNA2 CRISPRa kit - CRISPR gene activation of human interferon alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IFNA2
• Locus ID: 3440
• Kit Components:

  GA102327G1, Interferon alpha 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102327G2, Interferon alpha 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102327G3, Interferon alpha 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000605
• Synonyms: IFN-alphaA; IFNA; IFNA2B; INFA2
• Summary: 'This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]'