Human IFNAR2 activation kit by CRISPRa

CAT#: GA102340

IFNAR2 CRISPRa kit - CRISPR gene activation of human interferon alpha and beta receptor subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IFNAR2
• Locus ID: 3455
• Kit Components:

  GA102340G1, IFNAR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102340G2, IFNAR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102340G3, IFNAR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000874, NM_001289125, NM_001289126, NM_001289128, NM_207584, NM_207585
• Synonyms: IFN-alpha-REC; IFN-R; IFNABR; IFNARB; IMD45
• Summary: 'The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]'