Human IGF2 activation kit by CRISPRa

CAT#: GA102350

IGF2 CRISPRa kit - CRISPR gene activation of human insulin like growth factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IGF2
• Locus ID: 3481
• Kit Components:

  GA102350G1, IGF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102350G2, IGF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102350G3, IGF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000612, NM_001007139, NM_001127598, NM_001291861, NM_001291862
• Synonyms: C11orf43; GRDF; IGF-II; PP9974
• Summary: 'This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]'