Human ALS (IGFALS) activation kit by CRISPRa

CAT#: GA102352

IGFALS CRISPRa kit - CRISPR gene activation of human insulin like growth factor binding protein acid labile subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IGFALS
• Locus ID: 3483
• Kit Components:

  GA102352G1, ALS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102352G2, ALS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102352G3, ALS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146006, NM_004970, NR_027389
• Synonyms: ACLSD; ALS
• Summary: 'The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]'