Human IGFBP2 activation kit by CRISPRa

CAT#: GA102354

IGFBP2 CRISPRa kit - CRISPR gene activation of human insulin like growth factor binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IGFBP2
• Locus ID: 3485
• Kit Components:

  GA102354G1, IGFBP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102354G2, IGFBP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102354G3, IGFBP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000597, NM_001313990, NM_001313992, NM_001313993
• Synonyms: IBP2; IGF-BP53
• Summary: 'The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]'