Human IGFBP3 activation kit by CRISPRa

CAT#: GA102355

IGFBP3 CRISPRa kit - CRISPR gene activation of human insulin like growth factor binding protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IGFBP3
• Locus ID: 3486
• Kit Components:

  GA102355G1, IGFBP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102355G2, IGFBP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102355G3, IGFBP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000598, NM_001013398
• Synonyms: BP-53; IBP3
• Summary: 'This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]'