Human IL5RA activation kit by CRISPRa

CAT#: GA102385

IL5RA CRISPRa kit - CRISPR gene activation of human interleukin 5 receptor subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL5RA
• Locus ID: 3568
• Kit Components:

  GA102385G1, IL5RA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102385G2, IL5RA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102385G3, IL5RA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000564, NM_001243099, NM_175724, NM_175725, NM_175726, NM_175727, NM_175728
• Synonyms: CD125; CDw125; HSIL5R3; IL5R
• Summary: 'The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]'