Human CD130 (IL6ST) activation kit by CRISPRa

CAT#: GA102388

IL6ST CRISPRa kit - CRISPR gene activation of human interleukin 6 signal transducer

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL6ST
• Locus ID: 3572
• Kit Components:

  GA102388G1, CD130 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102388G2, CD130 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102388G3, CD130 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001190981, NM_002184, NM_175767, NR_120480, NM_001364276, NM_001364278, NR_157112, NM_001364275, NM_001364277, NM_001364279
• Synonyms: CD130; CDW130; GP130; IL-6RB
• Summary: 'The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]'