Human IL10RA activation kit by CRISPRa

CAT#: GA102397

IL10RA CRISPRa kit - CRISPR gene activation of human interleukin 10 receptor subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL10RA
• Locus ID: 3587
• Kit Components:

  GA102397G1, IL10RA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102397G2, IL10RA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102397G3, IL10RA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001558, NR_026691
• Synonyms: CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
• Summary: 'The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]'