Human IL12RB1 activation kit by CRISPRa

CAT#: GA102403

IL12RB1 CRISPRa kit - CRISPR gene activation of human interleukin 12 receptor subunit beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL12RB1
• Locus ID: 3594
• Kit Components:

  GA102403G1, IL12RB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102403G2, IL12RB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102403G3, IL12RB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001290023, NM_001290024, NM_005535, NM_153701
• Synonyms: CD212; IL-12R-BETA1; IL12RB; IMD30
• Summary: 'The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]'