Human IL15RA activation kit by CRISPRa

CAT#: GA102409

IL15RA CRISPRa kit - CRISPR gene activation of human interleukin 15 receptor subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL15RA
• Locus ID: 3601
• Kit Components:

  GA102409G1, IL15RA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102409G2, IL15RA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102409G3, IL15RA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243539, NM_001256765, NM_002189, NM_172200, NR_033494, NR_046362, NM_001351095, NM_001351096, NM_001351097
• Synonyms: CD215
• Summary: 'This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]'