Human Integrin Linked Kinase (ILK) activation kit by CRISPRa

CAT#: GA102417

ILK CRISPRa kit - CRISPR gene activation of human integrin linked kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ILK
• Locus ID: 3611
• Kit Components:

  GA102417G1, Integrin Linked Kinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102417G2, Integrin Linked Kinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102417G3, Integrin Linked Kinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014794, NM_001014795, NM_001278441, NM_001278442, NM_004517
• Synonyms: HEL-S-28; ILK-1; ILK-2; P59; p59ILK
• Summary: 'This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]'